Hemodynamics is an important bio-mechanic factor, which is implicated in the regulation and regeneration function inside the vessels. However, disturbing in its factors may cause development of many vascular diseases. Computational fluid dynamics (CFD) is alternative tool, which is used to assess hemodynamic factors inside complex cerebral vessels.

The purpose of this study is to assess the influence of the inlet waveforms under the same mean inflow on different hemodynamic factors inside Internal Carotid Arteries (ICA), using computational fluid dynamics combined to patient specific MRI images.

Four numerical models of (ICA) were reconstructed from 3D TOF MRI images. Navies-Stokes equations were solved inside the geometry using finite elements method. Sixteen simulations using four-inlet waveforms and four ICA arteries were performed to quantify the influence of the inlet waveform on blood flow inside ICA.

Varying the Inlet waveform boundary conditions has important effects on the overall instantaneous hemodynamic factors assessed on the geometries. However, time averaged factor assessed has been constant for individual cases.

Information about patient-specific inlet waveform is necessary for the accuracy of the patient-specific computation.


ICA ; CFD ; inlet waveform ; wall shear stress ; pressure

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R. J. Traystman, "Chapter 1 - Cerebrovascular Anatomy and Hemodynamics A2 - Caplan, Louis R," in Primer on Cerebrovascular Diseases (Second Edition), J. Biller, M. C. Leary, E. H. Lo, A. J. Thomas, M. Yenari, and J. H. Zhang, Eds., ed San Diego: Academic Press, 2017, pp. 5-12.

N. Westerhof, N. Stergiopulos, and M. I. Noble, Snapshots of hemodynamics: an aid for clinical research and graduate education: Springer Science & Business Media, 2010.

D. M. Sforza, C. M. Putman, and J. R. Cebral, "Hemodynamics of cerebral aneurysms," Annual review of fluid mechanics, vol. 41, pp. 91-107, 2009.

M. J. Cipolla, "The cerebral circulation," Integrated systems physiology: From molecule to function, vol. 1, pp. 1-59, 2009.

A. M. Malek, S. L. Alper, and S. Izumo, "Hemodynamic shear stress and its role in atherosclerosis," Jama, vol. 282, pp. 2035-2042, 1999.

J. Ando and K. Yamamoto, "Effects of shear stress and stretch on endothelial function," Antioxidants & redox signaling, vol. 15, pp. 1389-1403, 2011.

A. S. Turjman, F. Turjman, and E. R. Edelman, "Role of fluid dynamics and inflammation in intracranial aneurysm formation," Circulation, vol. 129, pp. 373-382, 2014.

M. Cibis, W. V. Potters, F. J. Gijsen, H. Marquering, E. VanBavel, A. F. Steen, A. J. Nederveen, and J. J. Wentzel, "Wall shear stress calculations based on 3D cine phase contrast MRI and computational fluid dynamics: a comparison study in healthy carotid arteries," NMR in Biomedicine, vol. 27, pp. 826-834, 2014.

J. R. Cebral, A. Radaelli, A. Frangi, and C. M. Putman, "Hemodynamics before and after bleb formation in cerebral aneurysms," in Medical Imaging, 2007, pp. 65112C-65112C-9.

M. S. Alnæs, J. Isaksen, K.-A. Mardal, B. Romner, M. K. Morgan, and T. Ingebrigtsen, "Computation of hemodynamics in the circle of Willis," Stroke, vol. 38, pp. 2500-2505, 2007.

V. C. Rispoli, J. F. Nielsen, K. S. Nayak, and J. L. Carvalho, "Computational fluid dynamics simulations of blood flow regularized by 3D phase contrast MRI," Biomedical engineering online, vol. 14, p. 110, 2015.

Y. Hua, J. H. Oh, and Y. B. Kim, "Influence of Parent Artery Segmentation and Boundary Conditions on Hemodynamic Characteristics of Intracranial Aneurysms," Yonsei medical journal, vol. 56, pp. 1328-1337, 2015.

A. Sarrami-Foroushani, M. N. Esfahany, H. S. Rad, K. Firouznia, M. Shakiba, and H. Ghanaati, "Effects of variations of flow and heart rate on intra-aneurysmal hemodynamics in a ruptured internal carotid artery aneurysm during exercise," Iranian Journal of Radiology, vol. 13, 2016.

M. Viceconti, S. Olsen, L.-P. Nolte, and K. Burton, "Extracting clinically relevant data from finite element simulations," Clinical Biomechanics, vol. 20, pp. 451-454, 2005.

M. A. Castro, M. C. A. Olivares, C. M. Putman, and J. R. Cebral, "Unsteady wall shear stress analysis from image-based computational fluid dynamic aneurysm models under Newtonian and Casson rheological models," Medical & biological engineering & computing, vol. 52, pp. 827-839, 2014.

J. R. Cebral, C. M. Putman, M. T. Alley, T. Hope, R. Bammer, and F. Calamante, "Hemodynamics in normal cerebral arteries: qualitative comparison of 4D phase-contrast magnetic resonance and image-based computational fluid dynamics," Journal of engineering mathematics, vol. 64, pp. 367-378, 2009.

D. Sekhane and K. Mansour, "Image-based Computational fluid dynamics (CFD) Modeling cerebral blood flow in the Circle of Willis," Journal of Advanced Research in Physics, vol. 6, 2016.

I. D. Šutalo, A. V. Bui, S. Ahmed, K. Liffman, and R. Manasseh, "Modeling of flow through the circle of Willis and cerebral vasculature to assess the effects of changes in the peripheral small cerebral vasculature on the inflows," Engineering Applications of Computational Fluid Mechanics, vol. 8, pp. 609-622, 2014.

D. Ivanov, A. Dol, O. Pavlova, and A. Aristambekova, "Modeling of human circle of Willis with and without aneurisms," Acta of Bioengineering and Biomechanics, vol. 16, pp. 121--129, 2014.

Y. Ren, G.-Z. Chen, Z. Liu, Y. Cai, G.-M. Lu, and Z.-Y. Li, "Reproducibility of image-based computational models of intracranial aneurysm: a comparison between 3D rotational angiography, CT angiography and MR angiography," Biomedical engineering online, vol. 15, p. 50, 2016.

D. Forti and L. Dedè, "Semi-implicit BDF time discretization of the Navier–Stokes equations with VMS-LES modeling in a High Performance Computing framework," Computers & Fluids, vol. 117, pp. 168-182, 2015.

L. Jing, J. Fan, Y. Wang, H. Li, S. Wang, X. Yang, and Y. Zhang, "Morphologic and hemodynamic analysis in the patients with multiple intracranial aneurysms: ruptured versus unruptured," PloS one, vol. 10, p. e0132494, 2015.

J. R. Cebral, M. Hernández, and A. F. Frangi, "Computational analysis of blood flow dynamics in cerebral aneurysms from CTA and 3D rotational angiography image data," in International congress on computational bioengineering, 2003, pp. 191-198.

M. D. Ford, N. Alperin, S. H. Lee, D. W. Holdsworth, and D. A. Steinman, "Characterization of volumetric flow rate waveforms in the normal internal carotid and vertebral arteries," Physiological measurement, vol. 26, p. 477, 2005.

Y. Hoi, B. A. Wasserman, E. G. Lakatta, and D. A. Steinman, "Carotid bifurcation hemodynamics in older adults: effect of measured versus assumed flow waveform," Journal of biomechanical engineering, vol. 132, p. 071006, 2010.

J. Xiang, A. Siddiqui, and H. Meng, "The effect of inlet waveforms on computational hemodynamics of patient-specific intracranial aneurysms," Journal of biomechanics, vol. 47, pp. 3882-3890, 2014.

P. M. McGah, M. R. Levitt, M. C. Barbour, R. P. Morton, J. D. Nerva, P. D. Mourad, B. V. Ghodke, D. K. Hallam, L. N. Sekhar, and L. J. Kim, "Accuracy of computational cerebral aneurysm hemodynamics using patient-specific endovascular measurements," Annals of biomedical engineering, vol. 42, pp. 503-514, 2014.

J. Jiang, K. Johnson, K. Valen-Sendstad, K.-A. Mardal, O. Wieben, and C. Strother, "Flow characteristics in a canine aneurysm model: a comparison of 4D accelerated phase-contrast MR measurements and computational fluid dynamics simulations," Medical physics, vol. 38, pp. 6300-6312, 2011.

F. P. Salvucci, C. A. Perazzo, J. G. Barra, and R. L. Armentano, "Assessment of pulsatile wall shear stress in compliant arteries: Numerical model, validation and experimental data," in Engineering in Medicine and Biology Society, 2009. EMBC 2009. Annual International Conference of the IEEE, 2009, pp. 2847-2850.

B. B. Lieber and C. Sadasivan, "Endoluminal scaffolds for vascular reconstruction and exclusion of aneurysms from the cerebral circulation," Stroke, vol. 41, pp. S21-S25, 2010.

A. Geers, I. Larrabide, H. Morales, and A. Frangi, "Approximating hemodynamics of cerebral aneurysms with steady flow simulations," Journal of biomechanics, vol. 47, pp. 178-185, 2014.

C. Karmonik, C. Yen, O. Diaz, R. Klucznik, R. G. Grossman, and G. Benndorf, "Temporal variations of wall shear stress parameters in intracranial aneurysms—importance of patient-specific inflow waveforms for CFD calculations," Acta neurochirurgica, vol. 152, pp. 1391-1398, 2010.

B. Chung and J. R. Cebral, "CFD for evaluation and treatment planning of aneurysms: review of proposed clinical uses and their challenges," Annals of biomedical engineering, vol. 43, pp. 122-138, 2015.

J. Schneiders, S. Ferns, P. van Ooij, M. Siebes, A. Nederveen, R. van den Berg, J. van Lieshout, G. Jansen, and C. Majoie, "Comparison of phase-contrast MR imaging and endovascular sonography for intracranial blood flow velocity measurements," American Journal of Neuroradiology, vol. 33, pp. 1786-1790, 2012.

J. Xiang, M. Tremmel, J. Kolega, E. I. Levy, S. K. Natarajan, and H. Meng, "Newtonian viscosity model could overestimate wall shear stress in intracranial aneurysm domes and underestimate rupture risk," Journal of neurointerventional surgery, pp. neurintsurg-2011-010089, 2011.


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