SCREENING PHYTOCHIMIQUE ET EVALUATION DE L’ACTIVITE ANTIMICROBIENNE DES ALCALOÏDES DES FEUILLES DE Peganum harmala L. RECOLTEES DANS LA REGION DE M’SILA

Auteurs-es

  • Nassima BEHIDJ BENYOUNES Université M’Hamed Bouguerra- Boumerdès (U.M.B.B.)
  • Thoraya DAHMANE Université M’Hamed Bouguerra- Boumerdès (U.M.B.B.)
  • Fadhila AKNOUCHE Université M’Hamed Bougarra- Boumerdès (U.M.B.B.)
  • Kamilia DEMMOUCHE Université M’Hamed Bougarra- Boumerdès (U.M.B.B.)

Mots-clés :

Peganum harmala, alkaloids, phytochemistry, antimicrobial activity, organisms, pathogens

Résumé

In this work, we have study a chemical characterization of extracts of leaves of a medicinal plant which is the Peganum harmala L. Peganum harmala L. is belonging to the Zygophyllaceae family. This characterization is followed by the determination of the evaluation of the antimicrobial activity of three extracts (éthanolique, aqueous and hexane) on microbial pathogens to know their effects on these organisms. Phytochemical tests on the three extracts showed that the plant has a wealth of alkaloids. This high content of alkaloids gave him a very toxic. This study shows that the three extracts have antibacterial effects against Gram + and some Gram - except for E. coli and P. aeruginosa. Thus an inhibitory effect on yeasts and molds should be mentioned.

Bibliographies de l'auteur-e

Nassima BEHIDJ BENYOUNES, Université M’Hamed Bouguerra- Boumerdès (U.M.B.B.)

Laboratoire de technologies douces, valorisation, physico-chimie des matériaux biologiques et   biodiversité, Faculté des sciences

Thoraya DAHMANE, Université M’Hamed Bouguerra- Boumerdès (U.M.B.B.)

Laboratoire de technologies douces, valorisation, physico-chimie des matériaux biologiques et   biodiversité, Faculté des sciences

Fadhila AKNOUCHE, Université M’Hamed Bougarra- Boumerdès (U.M.B.B.)

Département de Biologie, Faculté des sciences

Kamilia DEMMOUCHE, Université M’Hamed Bougarra- Boumerdès (U.M.B.B.)

Département de Biologie, Faculté des sciences

Références

- ISERIN P, "Encyclopédie des plantes médicinales",. Larousse (ed.), France, (2001), p. 335.

-CATIER O et ROUX D, "Botanique pharmacognosie phytothérapie",. Wolters Kluwer (ed.), Collection Porphyre, France, (2007), pp. 89-90.

- IBRAHIM D and OSMAN H. -Antimicrobial activity of Cassia alata from Malaysia. J Ethnopharmacology. Vol. 45. (1995). pp. 151-156.

- COWAN M M. Plant products as antimicrobial agents. Clinical Micro- biology Review. Vol. 12. (1999). pp. 564–582.

- AMMAR M, HAJEM B et LONGNAY G. Contribution à l’étude de l’activité biologique des feuilles de Cestrum parqui l’hérit sur le criquet pèlerin. Revue biotechnologie agronomie société et environnement. Vol. 5. (2001). pp. 85-90.

- TREKI S, AMINA, MERGHEM R. and DEHIMAT L. Etude phytochimique et évaluation de l’activite antibacterienne d’une labiee : Thymus hirtus. Sciences& Technologie N°29. (2009). pp.25-29.

- DUKE JAMES A. Handbook of Medicinal Herbs. Ed. CRC Press, Inc. Boca Raton, Florida.266 - 269.

- MASSOUD M., HOSSEIN J and PIROOZ S. Toxicity of Peganum harmala. Review and a Case Report: Iranian Journal of Pharmacology. Institute for Drug Research. Vol. 1. (2002).

- GOMAH N. Antibacterial and antifungal activities of (beta)-carboline alkaloids of Peganum harmala (L) seeds and their combination effects. Fitoterapia. Vol. 81. (2010). pp. 779–782.

- ABBASSI K, MERGAOUI L, ATAY-KADIRI Z, GHAOUT S, STAMBOULI A. Activités biologiques des feuilles de Peganum harmala (Zygophyllacea) en floraison sur la mortalité et l’activité génésique chez le criquet pèlerin Biological activities of Peganum harmala (Zygophyllacea) leaves at floral stage on the mortality and reproductive activity of the desert locust. Zoologica baetica. Vol. 16. (2005). pp. 31-46.

- HACHMI S, "Etude de l’activité antifongique d’extrait de Peganum harmala à l’égard de quelques champignons phytopathogènes",. Thèse Ingénieur. Ecole. Nationale. Supérieure. Agronomique, El – Harrach, (2010), p 75.

- DAHMANE T, "l’étude de l’activité nématicide de quelques extraits de plantes notamment Peganum harmala L. contre Meloidogyne incognita",. Thèse Magister. Ecole. Nationale. Supérieure. Agronomique, El – Harrach, (2010), p144.

- LEGER I E, " Techniques de l’ingénieur, génie de procédés chimiques J2. 782-3", (ed.), Debaene, France, (1989), pp. 360-860.

- SACCHETTI G, MAIETTI S, MUZZOLI M, SCAGLIANTI M, MANFREDINI S, RADICE M and BRUN R. Comparative evaluation of 11 essential oils of different origin as functional antioxidants, antiradicals and antimicrobials in foods. Food Chemistry. Vol. 91. (2005). pp. 621-632.

- CELIKTAS O Y, HAMES KOCABAS E E, BEDIR E, VARDAR SUK F, OZEK T and BASER K. H. C. Food Chemistry. Vol. 100. (2007). pp. 553-559.

- FAUCHERE J L et AVRIL J L, " Bactériologie générale et médicale",. Ellipses (ed.), France, Paris, (2002), p. 365.

- AL-DISSI N M, SALHAB A S and Al-HAJJ H A. Effects of Inula viscosa leaf extracts on abortion and implantation in rats. J Ethnopharmacol. Vol. 77. (2001). pp. 117–121.

- MONSEF H R, GHOBADI A, IRANSHAHI M, ABDOLLAHI M J. Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test. Pharmacy and Pharmaceutical Sciences. Vol. 7. (2004). pp 9. – 65.

- AL-SHAMMA A, DRAKE S, FLYNN D L, MITSCHER A, PARK Y H and RAO G S. Antimicrobial agents from higher plants, antimicrobial agent from Peganum harmala seeds. J of Natural Products. Vol. 44. (1981). pp. 440. – 745.

- ZHENLE C, ZHIBIN L, JINAO D, RONGHAN Z and SHOUXUN Z. Studies on the Volatile Constituents of Peganum Three Plants in China. J China Pharmaceutical University. Vol. 25. (1994). pp. 311-312.

- MUNIR C, ZAÏDI M I, AHMAD N, ATTA-UR-RAHMAN. An easy rapid metal mediated method of isolation harmine and harmaline from Peganum harmala. Fitoterapia. Vol. 66. (1995). pp. 73-76.

- Baba Aissa F., " Encyclopédie des plantes utiles, Flore d’Algérie et du Maghreb ",. Librairie moderne Ed. Rouiba, (1999), pp.235-236, 277-278.

- HILAL H W and YOUYG KEN., " Pharmaceutical Society of Egypt. National Information and Documentation Centre, (ed.), Cairo, Egypt, (1983), pp.123-243.

- KARTTAL M, ALTUN M, KURUCU S. HPLC method for the analysis of harmol, harmalol, harmine and harmaline in the seeds of Peganum harmala L.

J of Pharmaceutical and Biomedical Analysis. Vol. 31. (2003). pp. 9-263.

- MABRY T. J and ULUBELEN A., 1980 - Chemistry and utilization of phenylpropanoids including flavonoids, coumarins and lignans. J of Agriculture and Food Chemistry. Vol. 28. (1980). pp 188 - 196.

- BALENTINE C W, CRANDALL P G, O’BRYAN C A., DUONG D. Q. AND POHLMAN F. W. Natural Antioxidants in Meat Products. Meat Science. Vol. 73. (2006). pp 413-421.

- REZA V R M and ABBAS H. Cytotoxicity and antimicrobial activity of Harman alkaloids. J of Pharmacology and Toxicology. Vol. 2(7). (2009). pp 677–680.

- ALI-SHTAYEH M S, YAGHMOUR R M R, FAIDI Y R, SALEM K and AL-NURI M A. Antimicrobial activity of 20 plants used in folkloric medicine in the Palestinian area. Journal of Ethnopharmacology. Vol. 60. (1998). pp 265–271.

- SINGH U P, SRIVASTAVA J, KHOSA R. Effect of Ent-norsecurinine, an Alkaloid, on Spore Germination of Some Fungi. Folia Microbiology. Vol. 30(4). (2002). pp 225-227.

- NACOULMA O G, " Plantes médicinales et pratiques médicales traditionnelles: cas du Plateau central", Thèse de Doctorat d'État. Université d’Ouagadougou, Burkina Faso. (1996), p. 81.

- DHANDAPANI N, DHANDAPANI S., SUBRAMANIAN V. R., RAJAGOPALS and NAMASIVAYAM N. Antimicrobial activities of Iranian sumac and avishan shirazi against some food borne bacteria. Food Control. Vol. 18. (2002). pp. 646-649.

- IKHIRl K and ILAGOUMA A. T. Constituents of Detarium microcarpum. Fitoterapia. Vol. 66. (1995). pp. 266- 274.

- LAJIDE et al., 1995 LAJIDE L , ESCOUBA S P., MIZUTANI J. Termite antifeedant activity in Detariummi crocarpum. Phytochemistry. Vol. 40. (1995). pp. 1101-1104.

- MOORE P S et PIZZA C. Observations on the inhibition of HIV-1 reverse transcriptase by catechins. Journal Biochemical. Vol. 288. (1992). pp. 717-719.

- DIDRY N, PINKAS M et TORCK M., 1982 , "La composition chimique et l'activité antibactérienne des feuilles de diverses espèces de grindelia" Pl. Med. Phytother. p. 7.

-RAVN H, ANDARY C, KOVACS G and MOLGAARD P. Caffeic acid esters as in vitro inhibitors of plant pathogenic bacteria and fungi. Biochemical Systematics and Ecology journal. Vol. 17. (1984). pp. 175 - 184.

- (1985) REES S and HARBORNE J B. 1985 - The role of sesquiterpene lactones and phenolics in the chemical defence of the chicory plant. Phytochemistry. Vol. 24. (1985). pp. 2225 – 2231.

- KOLODZIEJ H, KAYSER O 1, LATTE P K and FERREIRA D. Evaluation of the anti-microbial potency of tannins and related compounds using the rnicrodilution broth method. Planta Medica. Vol. 65. (1999). pp. 444 - 446.

- AMVAM ZOLLO P H, BIVITI L, TCHOUMBOVGNANG F, MENUT C, LAMATV G and BOUCHET PH. Aromatic plants of Tropical Central Africa, Part Chemical composition and antifungal activity of thirteen essential oils from aromatic plants of Cameroon. Flavor and Fragrance Journal. Vol. l. (1998). pp. 107-114.

- SHAN B, CAI Y Z, BROOKS J D and CORKE H. The in vitro antibacterial activity of dietary spice and medicinal herb extracts. J International Food Microbiology. Vol. 117. (2007). pp. 112-119.

- ASKUN, T., TUMEN, G., SATIL, F and ATES M., 2009 - In vitro activity of methanol extracts of plants used as spices against Mycobacterium tuberculosis and other bacteria. Food Chemistry. Vol. 116. (2009). pp 289-294.

- LAMCHOURI F,SETTAF A,CHERRA Y, HASSAR M, ZEMZAMI M, ATIF N, NADORI E B ZAID A and LYOUSSI B. In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines. Fitoterapia. Vol.71. (2000). pp. 50-54.

Téléchargements

Publié-e

2015-12-01

Comment citer

BEHIDJ BENYOUNES, N., DAHMANE, T., AKNOUCHE, F., & DEMMOUCHE, K. (2015). SCREENING PHYTOCHIMIQUE ET EVALUATION DE L’ACTIVITE ANTIMICROBIENNE DES ALCALOÏDES DES FEUILLES DE Peganum harmala L. RECOLTEES DANS LA REGION DE M’SILA. Sciences & Technologie. C, Biotechnologies, (42), 21–30. Consulté à l’adresse https://revue.umc.edu.dz/c/article/view/2033

Numéro

N° 42 Décembre 2015

Rubrique

Articles