PATTERNS OF CIRCULATING FSH AND LH IN OULED DJELLEL EWE LAMBS DURING POSTNATAL DEVELOPMENT
Keywords:
Ouled djellel, FSH, LH, Antral follicles, postnatal developmentAbstract
Plasma was collected for hormone measurement from 150 Ouled Djellel ewe lambs, born in September, at 0 (< 24 hours), 1, 4, 6, 8, 10, 12, 14, 16, 18, 20, 22, 24, and 26 weeks, and at 1 year of age. Four of the ewe lambs were slaughtered at each of the time points. The ovaries of the slaughtered lambs were weighed; antral follicles≥3mm in diameter were counted and their size was measured on histological ovarian sections. Concentrations of follicle stimulating hormone (FSH) and luteinizinghormone (LH) in plasma increased from birth to 10 weeks of age, and then declined to levels similar to those of yearling, sexually mature ewes. The level of LH then rose again to reach a second peak at 24 weeks of age, which represented the preovulatory LH surge. The variation in the concentrations of the hormones was accompanied by an initial increase in ovarian weight and maximum follicle diameter at 10 weeks of age, and a second increase in these ovarian characteristics at 18 weeks of age.
These data suggest that Ouled Djellel ewes reach puberty early, at 24 weeks of age, and that there is a relationship between the variations in plasma concentrations of FSH and LH and the changes in follicular populations of antral follicles at certain ages.
References
- Fortune J.E., ″Ovarian follicular growth and development in mammals″, Biol. Reprod., Vol. 50, Iss 2., (1994), pp. 225-232.
- Elizabeth A., Mcgee, Aaron J., Hsueh, W., ″ Initial and cyclic recruitment of ovarian follicles″, Endocrine. Reviews., Vol.21, Iss 2, (2000), pp. 200-214.
- Deepak A., Kui., ″Molecular Mechanisms Underlying the Activation of Mammalian Primordial Follicles″, Endocrine. Reviews., Vol.30, Iss 5, (2009), pp. 438-464.
- Driancourt M. A., ″Regulation of ovarian follicular dynamics in farm animals. Implications for manipulation of reproduction″, Theriogenology, Vol. 55, Iss 6., (2001), pp. 1211-1239.
- Edson M. A., Ankur K. N., Martin M. M.,″ The Mammalian ovary from genesis to revelation″, Endocrine. Reviews., Vol.30, (2009), pp. 624-712.
- Evans A.C., ″Characteristics of ovarian follicle development in domestic animals″ Reprod. Domest. Anim., Vol. 38, Iss 4, (2003), pp. 240-246.
- Driancour M.A., ″Follicular dynamics in sheep and cattle″, Theriogenology., 35, (1991), pp. 35-79.
- Foster D., Ryan K.D., “Mechanisms govering onset of ovarian cyclicity at puberty in the lamb”, Ann. Biol. Biophys., 19(4B), 1979), pp. 1369-1380.
- Georgieva R.I., Bulahbel S., Georgiev H.G., “Patterns in FSH, LH and 17β-Estradiol during the postnatal development of sheep“, Theriogenology., 41, (1994), pp. 729-
- Kathleen D.R., Goodman R.L., Karsch F.J., Legan S.J. Foster D.L., “Patterns of circulating gonadotropins ovarian steroids during the first periovulatory period in the developing sheep”, Biol. Reprod., 45, (1991), pp. 471-477.
- Foster D., Ryan K.D., Papkoff H., “Hourly administration of luteinizing hormone induces ovulation in the prepubertal lamb”, Endocrinology., 115, (1984), pp. 1179-1185.
- Keisler D.H., Inskeep E.K., Dailey R.A., “Roles of pattern of secretion of luteinizing hormone and the ovary in attainment of puberty in ewe lambs”, Anim. Endocrinol., 2, (1985), pp. 123-132.
- Shierley K.L, Hermandez D.M., Halford D.M, Thomas M.G., ″Serum luteinizing hormone, growth hormone and insulin-like growth factor-I after releasing hormone challenge in prepubertal ewe lambs selected for twinning″, Theriogenology., 56, (2001), pp. 867-877.
- Fitzgerald J., Butler W.R., “Seasonal effects and hormonal patterns related to puberty in ewe lambs”, Biology. Reprod., 27, (1982), pp. 853-863.
- Jorio A., Mariana J.C., Lahluo-Kassi A., “Development of the population of ovarian follicles during the prepubertal period in D’man and Timahdite sheep”, Anim. Reprod. Science., 26, (1991), pp. 239-250.
- Matteri R.L., Roser J.F., Baldwin D.M.,″Characterization of monoclonal antibody which detects luteinizing hormone from diverse mammalian species″, Domestic. Anim. Endocrinol., Vol.4, Iss 3, (1987), pp. 157-165
- Dirnhofer S., Lechner O., Klieber R., Leeuw R., Widk G., Berger P., ″ Free alpha subunit of human chorionic gonadotropin: molecular basis of immunologically and biologically active domaine ″, J. Endocrinol., 140, (1994) pp. 145-154.
- Tassel R., Chamley W., Kennedy J.P., “Gonadotropins levels and ovarian development in the neonatal ewe lamb”, Aust. J. Biol. Sci., 31, (1978), pp.267-273.
- Tassel R., Chamely W., Kennedy J.P., “Gonadotrophines in the neonatal female lamb”, J. Reprod. Fertil., 46, (1976), pp. 515 abstr.
- Douglas L. Foster J.A., Robert B., Jaffe A., Lemons., Gordon D., Niswender., “Sequential patterns of circulating luteinizing hormone and folliclestimulating hormone in female sheep from early postnatal life through the first estrous cycles”, Endo., Vol. 97, N°4 (1975), pp. 985-993.
- Foster D.L., Roach JF, Karsch F.J., Norton H.W.,
Cook B., Nalbandov A.V., “Regulation of luteinizing hormone in the foetal and neonatal lamb”, Endocrinol., 90 (1972), pp. 102 -113.
- Driancourt M.A., Gibson W.R., Cahill L.P., “Follicular dynamics throughout the oestrus cycle in sheep. A review“, Reprod. Nutr. Dev., 25, (1985), pp. 1-15.
- Driancourt M.A., Gougeon A., Royere D., Thibault C., “Ovarian function”. In Reproduction in mammals and man. RHF hunter editions. Paris, Ellipses, (1993), pp. 281-305.
- Dufour J., Cahill L.P., Mauleon P., “Short-and longterm effects of hypophysectomy and unilateral ovariectomy on ovarian follicular populations in sheep”, J. Reprod. Fertil., 57, (1979), pp. 301-307.
- Driancourt M.A., Fry R.C., Clarke U., Cahill L.P, “Follicular growth and regression during 8 days after hypophysectomy in sheep”, J. Reprod. Fertil., 79, (1987), pp. 635-641.
- Bartlewski P.M, Beard A.P., Cook S.J., Rawlings N.C., “Ovarian activity during sexual maturation and following introduction of the ram to ewe lambs”, Small. Ruminant. Research., 43, (2002), pp. 37-44.
- Driancourt M., “Variations in patterns of follicle
development in prolific breeds of sheep”., J. Reprod. Fertil., 78, (1986), pp. 565-575.
- Kennedy J.P., Worthington C.A., Cole E.R., “The post-natal development of the ovary and uterus of the Merino lamb”, J. reprod. Fertil, 36, (1974), pp. 275-282.
- Douglas L. Foster., Jaffe R.B. Gordon D., Niswender.,
“Sequential patterns of circulating LH and FSH in female sheep during the early postnatal period: Effect of gonadectomy”, Endocrinology., 96, (1975), pp. 15-22.
- Rawlings N.C., Churchill I.J., ″Effect of naloxane on gonadotrophin secretion at various stages of development in the ewe lamb”, J. Reprod. Fertil., 89, (1990), pp. 503-509.
- Foster D.L., Karsch F.J.,“ Development of the mechanism regulating the preovulatory surge of luteinizing hormone in sheep”, Endocrinology., 97, (1975), pp. 1205-1209.
- Liefer R.W., Foster D.L., Dziuk P.J., “Levels of LH in the sera and pituitaries of female lambs following ovariectomy and administration of oestrogen”, Endocrinology., 90, (1972), pp981-985
- Kinde J.E., Day M.L., Kittot R.J., “Endocrine regulation of puberty in cows and ewes”, J. Reprod. Fertil., Suppl., 34, (1987), pp. 167-186.
- Keisler D.H., Inskeep E.K., Dailey R.A., “Roles of pattern of secretion of luteinizing hormone and the ovary in attainment of puberty in ewe lambs”, Anim. Endocrinol., 2, (1985), pp. 123-132.
- Carson R.S., Findlay J.K., Burger H.G., Trounson A.O., “Gonadotropin receptors of the ovine ovarian follicle during follicular growth and atresia”, Biol. Reprod., 21, (1979), pp. 75-87.
- Tsonis C.G., Carson R.S. Findlay J.K., “Relationships between aromatase activity, follicular fluid oestradiol-17B and testosterone concentrations and diameter and atresia of individual ovine follicles”, J. Reprod. Fertil., 72 (1984), pp. 153-163.
- Zeleznik A.J., Midgleyjr A.R., Reichertjr L.E., “Granulosa cell maturation in the rat: increased binding of human chorionic gonadotropin following treatment with follicle stimulating hormone” Endocrinology., 95, (1974), pp. 818-825.
- McNatty K.P., Lun S., Heath D.A., O’Keefe L.E., “Ovarian follicular activity in Booroola lambs with and without a fecundity gene”, J. Reprod. Fertil., 79, (1987), pp. 57-66.
- Akchiche O., Variations saisonniéres des concentrations plasmatiques en progestérone et en LH (hormone luteinisante) chez la brebis de race Ouled-Djellel en Algérie », Thèse de 3eme cycle : physiologie animale et endocrinologie., Univ. Sci. Tech. Houari. Boumedienne., (1983), 131pp.
- Ravindra J.P., Rawlings N.C., Evans A.C.O., Adams G.P., “ultrasonographic study of follicular dynamics in ewes during the oestrus cycle”, J. Repro. Fertil., (1994), pp. 501-509.
- Bartlewski P.M. Beard A.P., Rawlings N.C., “An ultrasonographic study of luteal function in breeds of sheep with different ovulation rates”, Therigenology., 52, (1999), pp.115-130.
-Castonguay P.D., Dufour J.J., Minivell F., Estrada R., “Follicular dynamics and dominance in Booroola x Finnish Landrace and Booroola x Suffolk ewes heterozygous for the F gene”, J. Reprod. Fertil., 89, (1990), pp. 193-203.
- Bartlewski P.M. Beard A.P., Cook S.J., Chandolia R.K. Honaramooz A., Rawlings N.C., “Ovarian antrale follicular dynamics and their relationships with endocrine variables throughout the oestrus cycle in breeds of sheep differing in prolificacy”, J. Reprod. Fertil., 115, (1999), pp. 11-124.
- Scaramuzzi R.J., Radford H.M., “Factors regulating ovulation rate in the ewe”, J. Reprod. Fertil., 69, (1983), pp. 353-367.
- Wheeler A.G., Land R.B., “Seasonal variations in oestrus and ovarian activity of Finnish Landrace, Tasmanian merino and Scottich blackface ewes”, Anim. Prod., 24, (1977), pp. 363-372.
- Driancourt M.A., Hermier D., Hanrahan J.P., “Alterations in follicular function associated with selection on ovulation rate in Finn ewes”, J. Anim. Scien., 74, (1996), pp. 199-210.
- Bartlewski P.M. Beard A.P., Rawlings N.C., “Ovarian function in ewes at the onset of breeding season”, Anim. Prod., 57, (1999), pp. 67-88.
- Driancourt M.A., ″Turnover of large ovarian follicles: When, how, why? ″, Theriogenology., (2001)
- Baired D.T., Land R.B., Scaramuzzi R.J., Wheeler A.G., « Gonadotrophic control of follicular development and function during the oestrus cycle of the ewe”, J. Endocrinol., 69, (1976), pp. 275-286.
- Campebell B.K., Scaramuzzi R.J., Webb R., “Control of antral follicle development and selection in sheep and cattle”, J. Reprod. Fertil. Suppl, 49, (1995), pp. 335-350.
- Campbell B.K., Telfer H., Scaramuzzi R.J., “Evidence of a role for follicle stimulating hormone in controlling the rate of preantral follicle development in sheep”, Endocrinol., 145, (2004), pp. 1870 -1879.
- Quirke J.F., Stabenfeld G.H., Bradford G.E., “Onset of puberty and duration of the breeding season in Suffolk, Rambouillet, Finnish Landrace, Dorset and Finn-Dorset ewe lambs”, J. Anim. Sci., 60, (1985), pp. 1463-1471.
