EFFET DE LA PARATHYROÏDECTOMIE (PTX) SUR L’EVOLUTION DE LA PRESSION ARTERIELLE CHEZ LES RATS MALES ET FEMELLES DE SOUCHE SPONTANEMENT HYPERTENDUE (SHR)
Keywords:
Parathyroïdectomie, Pression artérielle, Sexe, Age, rat spontanément hypertenduAbstract
L’ablation chirurgicale des parathyroïdes (PTX) effectuée au sevrage ralentit le développement de l’hypertension chez les rats mâles de souches Lyonnaise (LH) et spontanément hypertendu (SHR). Dans ce travail nous avons cherché à étudier l’effet de la parathyroïdectomie sur l’évolution de la pression artérielle systolique (PAS) chez les rats jeunes et âgés mâles et femelles de souche SHR. Les valeurs obtenues du calcium plasmatique total (mmol/L) mesurés à l’âge de 6, 10, 22 et à 36 semaines indiquent une diminution significative (p<0,001) de la calcémie (d’environ 30 %) chez les rats parathyroïdectomisés (PTX) mâles et femelles, avec un redressement significatif (p<0,05) de la calcémie avec l’âge chez rats femelles. La PTX ralentit l’élévation de la pression artérielle (p<0,01) chez les rats jeunes et âgés mâles SHR, par contre la PAS n’est pas significativement modifiée après parathyroïdectomie chez les femelles et durant toute la période d’essai. En conclusion, l’absence de l’effet de la parathyroïdectomie sur l’évolution de la PAS chez les rats jeunes et âgés femelles est probablement liée au redressement de la calcémie et à l’implication directe et/ou indirecte des facteurs biologiques liés au sexe qu’à la souche hypertendue SHR.References
- MacCarron D.A., Pang N.N., Ugoretz B.A. & Krutzik S., Distrubances of calcium metabolism in the spontaneously hypertensive rat ; Hypertens. 2 (1). (1981). pp. 162-167.
- Schleiffer R., Berthelot A., Pernot F. & Gairard A., Parathyroids, thyroid and development of hypertension in SHR. Jpn Circ. J. 45. (1981). pp. 1272-1279.
- Resnick L.M., Nicholson J.P. & Laragh J.H., Calcium metabolism and the renin-aldosterone system in essential hypertension. J Cardiovasc Pharmacol. 7. (6). (1985). pp. S187-S193.
- Lhoste F., drueke T., Larno S. & Boissier J.R., Cardiac interaction between parathyroid hormone, beta adrenoceptor agents and verapamil in the guinea pig in vitro. Clin Exp Pharmacol Physiol. 7. (1980). pp. 119-127.
- Bogin E., Massry S.G. & Harary I., Effect of parathyroid hormone on rat heart cells. J Clin Invest. 67. (1981). pp. 1215-1227.
- Cheng S.P., Yang T.L., Lee J.J., Chen H.H., Wu C.J., Liu T.P. & Liu C.L., Gender differences among patients with secondary hyperparathyroidism undergoing parathyroidectomy. J Surgical Research. 168. (2011). pp. 82-87.
- Pang P.K.T. & Lewanczuk R.Z., Parathyroid origin of new circulating hypertensive factor in spontaneously hypertensive rats. Am J Hypertens. 2. (1989). pp. 898-902.
- Lewanczuk R.Z., Chen A. & Pang P.K.T., The effect of dietary calcium on blood pressure in spontaneously hypertensive rats may be mediated by parathyroid hypertensive factor. Am J Hypertens. 3. (1990). pp. 349-353.
- McCarron D.A., Low serum concentrations of ionized calcium in patients with hypertension. Eng J Med. 307. (1982). pp. 226-228.
- Strazzullo P., Nunziata V., Cirillo M., Giannattasio R., Ferrara L.A., Mattioli P.L., Mancini M., Abnormalilies of calcium metabolism in essential hypertension. Clin Sci. 65. (1983). pp. 137-141.
- Pernot F., Schleiffer R., Bergmann C., Vincent M., Sassard J. & Gairard A., Dietary calcium, vascular reactivity and genetic hypertension in the Lyon rat strain. Am J. Hypertens. 3. (1990a). pp. 846-853.
- Berthelot A., Gairard A., Goyault M. & Pernot F., Relation between calcium and cardiovascular reactivity in mineralocorticoid-induced hypertension in the rat. Br J Pharmacol. 70. (1980). pp. 301-306.
- Pernot F., Schleiffer R., Vincent M., Sassard J. & Gairard A., Parathyroidectomy in the Lyon hypertensive rat: cardiovascular reactivity and aortic responsiveness. J Hypertens. 8. (1990b). pp. 1111-1117.
- Boulebda N., Van Overloop B. & Gairard A., Endothelium-derived relaxing factor, hypertension and chronic parathyroidectomy in spontaneously and Wistar-Kyoto rats, Exper Pharmacol Physiol. 20. (1993). pp. 773-785.
- Gairard A., Berthelot A., Schleiffer R. & Pernot F., Parathyroidectomy significantly decreases hypertension in spontaneously hypertensive and deoxycoticosterone plus saline treated rats. Can J Physiol Pharmacol. 60. (1981). pp. 208-212.
- Schleiffer R., Pernot F. & Gairard A., Parathyroidectomy, cardiovascular reactivity and calcium distribution in aorta and heart of spontaneously hypertensive rats. Clin Sci. 71. (1986). 505-511.
- Kesteloot H., Epidemiological studies on the relationship between sodium, potassium, calcium, and magnesium and arterial blood pressure. J Cardiovasc Pharmacol. 6. (1). (1984). pp. S192-S196.
- Nakamura R. & Saruta T., Effect of calcium supplementation on blood pressure in essential hypertensive subjects, Jpn J Med. 26. (1987). pp. 203-206.
- Mangiarua E.I., Wright G.L., Rankin G.O. & McCumbee W.D., Hypertensive factor in different models of experimental hypertension. Arch Int Physiol Biochem Biophys. 99. (1991). pp. 309-313.
- Oshima T., Schleiffer R., Young E.M., McCarron D.A. & Bukoski R.D., Parathyroidectomy lowers blood pressure independently in platelet free calcium. J Hypertens. 9. (1991). pp. 155-158.
- Lempert U.G., Scharia S.H., Minne H.W. & Ziegler R., Influence of parathyroidectomy, 1,25 dihydroxyvitamin D3 and high dietary calcium intake on demineralized bone matrix powder-induced bonne formation in the rat. Bone and Mineral. 13. (1991). pp. 103-109.
- Minizola S., Pacitti M.T., Scarda A., Rosso R., Romagnoli E., Carnevale V., Scarnecchia L. & Mazzuoli F., Serum ionized calcium, parathyroid hormone and related variables: effect of age and sexe. Bone and Mineral. 23 (3). (1993). pp. 183-193.
- Wright G.L. & Rankin G.O., Concentrations of ionic and total calcium in four models of hypertension. Am J Pharmacol. 243. (1982). pp. H365-H370.
- Schedli H.P., Miller D.L., Pape J.M., Horst R.L. & Wilson H.P., Calcium and sodium transport and vitamin D metabolism in the spontaneously hypertensive rat. J Clin Invest. 73. (1984). pp. 731-734.
- Tam C.S., Heersche J.N.M., Murray T.M. & Persons J.A., Parathyroid hormone stimulates the bone opposition rate independently of its resorptive action: differential effects of intermittent and continuous administration. Endocrinology. 110. (1982). pp. 506-510.
- Lucas P.A., Brown R.C., Dreke T., Lacour B., Merz J.A. & McCarron D.A., Abnormal vitamin D metabolism, intestinal calcium transport and bone calcium status in the spontaneously hypertensive rat compared with its genetic control. J. Clin. Invest. 78 (1). (1986). pp. 221-227.
- Bindels R.J.M., Van den Broek L.A.M., Longen M.J.M., Hackeng W.H.L., Lowik C.W. & Van Os C.H., Increased plasma calcitonin levels in young spontaneously hypertensive rat: role in disturbed phosphate hemeostasis. Pfluegers Arch. 408. (1987). pp. 395-400.
- Pernot F., Luthringer C., Vincent M., Sassard J., Berthelot A. & Gairard A., Calcium metabolism in the Lyon hypertensive rat. Ann. Nutr. Metab. 35. (1991). pp. 45-52.
- Schull J., Walker J., Fitzgerald K., Hiilivirta L., Ruckdeschel J., Schumacher D., Stanger D. & McEachron D.L., Effects of sex, thyro-parathyroidectomy, and light regime on levels and circadian rhythms of wheel-running in rats. Physiology & Behavior. 46 (3). (1989). pp. 341-346.
- Haden S.T., Brown E.M., Hurwitz S., Scott J. & Ghada El-Hajj F., The effects of age and gender on parathyroid hormone dynamics. Clin Endocrinol. 52. (2000). pp. 329-338.
- Richert L., Trombetti A., Hermann F.R., Triponez F., Robert M.C. & Rizzoli R., Age and gender distribution of primary parathyroidism and incidence of surgical treatment in a European country with a particularly high life expectancy. SWISS MED WKLY. 169 (27-28). (2009). pp. 400-404.
- Logue F.C., Fraser W.D., Gallacher S.J., Cameron D.A., O'Reilly D.S., Beastall G.H., Patel U., Boyle I.T., The loss of circadian rhythm for intact parathyroid hormone and nephrogenous cyclic AMP in patients with primary hyperparathyroidism. Clin. Endocrinol. 2. (1990). pp. 475-483.
- Kitamura N., Shigeno C., Shiomi K., Lee K., Ohta S., Sone T., Katsushima S., Tadamura E., Kousaka T., Yamamoto I., Episodic fluctuation in serum intact parathyroid hormone concentration in men. J Clin Endocrinol Metab. 70. (1990). pp. 252-63.
- Calvo M.S., Eastell R., Offord K.P., Bergstralh E.J., Burritt M.F., Parathyroid transplantation in Lyon and Milan strains: preliminary results on blood pressure. Genetic Hypertension. J Clin Endocrinol. Metab. 72. (1991). pp. 69-76.
- Samuels M.H., Veldhuis J., Cawley C., Urban R.J., Luther M., Bauer R., Mundy G., Pulsatile
secretion of parathyroid hormone in normal young subjects: assessment by deconvolution
analysis. J Clin Endocrinol Metab. 77. (1993). pp. 399-403.
- Rudnicki M., Thode J., Jorgensen T., Heitmann B.L. & Sorensen O.H., Effects of age, sex, season and diet on serum ionized calcium, parathyroid hormone and vitamin D in a random population. J Inter Med. 234 (2). (1993). 195-200.
- Migliardi M. & Marranca D., The parathyroid hormone measurement: variation factors and standardisation problems, Immuno-analyse & Biologie Spécialisée. 21 (2). (2006). pp. 119-126.
- Mann J.E.F., Wiecek A., Bommer J., Ganten U. & Ritz E., Effects of parathyroidectomy on blood pressure in spontaneously hypertensive rats. Nephron. 45. (1987). pp. 46-52.
- Berthelot A., Schleiffer R. & Gairard A., Parathyroïdes et hypertension artérielle à l’acétate de déoxycorticostérone chez le rat, Can. Can J Physiol Pharmacol. 57. (1979). pp. 157-162.
- Boulebda N., Endothélium et réactivité vasculaire aortique chez le rat spontanément hypertendu (SHR): Effet de la parathyroidectomie. Thèse d’état, 1993.Université Louis pasteur, Strasbourg, France.
- Lewanczuk R.Z. & Pang P.K.T., The importance of parathyroid glande in some forms of essential hypertension [abstract], Hypertension, 14 (1989), pp. 332.
- Valvo E., Bedogna V., Gammaro L., Casagrande P., Ortalda V. & Maschio G., Systemic hemodynamic pattern in primary hyperparathyroidism and its changes after parathyroidectomy. Electrolyte. Metab. 17. (1991). pp. 147-152.
- Heyliger A., Tangpricha V., Weber C. & Sharma J., Parathyroidectomy decreases systolic and diastolic blood pressure in hypertensive patients with primary hyperparathyroidism. Surgery. 146. (2009). pp. 1042-1047.
- Broulik P.D., Brouliková A., Adámek S., Libanský P., Tvrdoň J., Broulikova & Kubinyi J., Improvement of hypertension after parathyroidectomy of patients suffering from primary hyperparathyroidism. Inter J Endocrinol. 2011. Article ID 309068, 6 pages doi:10.1155/2011/309068.
- Rydberg E., Birgander M., Bondeson A-G., Bondeson L. & Willenheimer R., Effect of successful parathyroidectomy on 24-hour ambulatory blood pressure in patients with primary hyperparathyroidism. Inter J Cardiol. 142. (2010). pp. 15-21
- Mizrachi, A., Gilat H., Bachar G., Feinmesser R. & Shpitzer T., Elevated parathyroid hormone levels after parathyroidectomy for primary hyperparathyroidism. Head & Neck. 31 (11). (2009). pp. 1456-160.
- Neuser D., Schulte-Brinkmann R. & Kazda S., Development of hypertension in WKY rats after transplantation of parathyroid glands from SHR/SP. J Cardiovasc Pharmacol. 6. (1989). pp. 971-974.
- Burkard C., Vincent M., Ferrari P., Sassard J. & Gairard A., Parathyroid transplantation in Lyon and Milan strains: preliminary results on blood pressure. Genetic Hypertension. Ed J Sassard. Coloque INSERM/John Libbey Eurotext Ltd. 218 (1992). pp. 577-579.
- Churina S.K., Klueva N.Z., Eschanova G.T. & Ryzhof D.B., Gender differences among patients with secondary hyperparathyroidism undergoing parathyroidectomy. Bull Exp Biol Med. 115. (1993). pp. 128-130.
