STUDY ON ADAPTIVE CAPACITY AND BEHAVIORAL STRESS OF SEPARATION (MOTHER-JUVENILE) IN RATS WISTAR
Keywords:
Adaptive capacity, Stress separation, genetic environmental factors, ratAbstract
In humans, genetic and environmental factors influence susceptibility to many diseases. In particular, the quality of relationships between a child and his mother plays an important role for the harmonious development and the subsequent equilibrium of this individual. Perturbations of these relationships can lead to such serious psychiatric disorders. More, experimental animal models are developed in order to know the neurobiological disturbances that underlie vulnerability to these disorders. Modeling animal remains relative. The work presented in this paper was carried out on a model of mother / newborn rats (Tusrattus) of the Wistar strain separation. The rats are separated from their mothers and isolated from conspecifics daily for 5 min, 30 min and an hour of their third to their 14th day of life. Studies have already been conducted in this model, in rats became adults. It was this time to analyze the behavior of rats at the age juvénile. The first part presents the general context within forms the subject, and includes bibliographic data models . The second part presents the specific objectives of the work. It will be followed by a third part describes the experimental work. Different behavioral realized tests will be explained, and then the results explain that the longer duration of separation increases behavioral responses, compared to those in the literature.References
. Russak LG, Schwartz GE. Feelings of parental care predict health status in midlife: a 35-year follow-up of Harvard Mastery of Stress Study. J Behav Med. 20. (1997). pp:1–11.
. Spitz RZ. Anaclitic depression: an inquiry into the genesis of psychiatric conditions of early chilhood. Psychoanal Stud Child.2. (1946). pp: 313-7.
. Holmes RD, Robbins LN. The influence of childhood disciplinary experience on the development of alcoholism and depression. J Child Psychol Psychiatry. 28. (1987). pp:399–415.
. Bifulco A, Harris T, BrownGW. Mourning or earlyinadequate care? Reexamining the relationship of maternal loss in childhood with adult depression and anxiety. DevPsychopathol.4.(1992). pp:433-49.
. Canetti L, Bachar E, Galili-Weisstub E, De-Nour AK, ShalevAY.Parental bonding and mental health in adolescence. Adolescence. 32. (1997). pp:381–394.
. Hall FS. Social deprivation of neonatal, adolescent, and adult rats has distinct neurochemical and behavioral consequences. Crit Rev Neurobiol. 12. (1998). pp:129–162.
. Anisman H, Zaharia MD, Meaney MJ, Meralis Z. Do early life events permanently alter behavioral and hormonal responses to stressors?Int J DevNeurosci. 16. (1998). pp:149–164.
. Meaney MJ, Aitken DH, Sharma S, Viau V, Sarrieau A. Postnatal handled increases hippocampal type II, glucocorticoid receptors and enhances adrenocortical negative –feedback efficacy in the rat. Neuroendocrinology. 51. (1989). pp:597–604.
. Vallee M, Maccari S, Dellu F, Simon H, Le Moal M, Mayo W. Long-term effects of prenatal stress and postnatal handling on age-related glucocorticoid secretion and cognitive performance: a longitudinal study in the rat. Eur J Neurosci. 11. (1999). pp:2906–2916.
. Levine S, Haltmeyer GC, Karas GG, Denenberg VH. Physiological and behavioral effects of infantile stimulation. PhysiolBehav.2. (1967). pp:55–59.
. Ogawa T, Mikuni M, Kuroda Y, Muneoka K, Mori KJ, Takahashi K. Periodic maternal deprivation alters stress response in adult offspring; potentiates the negative feedback regulation of restraint stress-induced adrenocortical response and reduces the frequencies of open field-induced behaviors. PharmacolBiochemBehav.49. (1994). pp:961–967.
. Liu D, Diorio J, Tannenbaum B, Caldji C, Francis D, Freedman A, Sharma S, Pearson D, Plotsky PM, Meaney MJ. Maternal care, hippocampal glucocorticoid receptors, and hypothalamic–pituitary–adrenal responses to stress. Science. 277. (1997). pp: 1659–1662.
. Francis DD, Caldji C, Champagne FN, Plotsky PM, Meaney MJ. The role of corticotropin-releasing factor-norepinephrine systems in mediating the effects of early experience on the development of behavioral and endocrine responses to stress. Biol Psychiatry. 46. (1999). pp:1153–1166.
. Wigger A, Neumann ID. Periodic maternal deprivation induces gender-dependent alterations in behavioral and neuroendocrine responses to emotional stress in adult rats. PhysiolBehav. 66. (1999). pp:293–302.
. Huot RL, Thrivikraman KV, Meaney M, Plotsky PM. Development of adult ethanol preference and anxiety as a consequence of neonatal maternal separation in Long–Evans rats and reversal with antidepressant treatment. Psychopharmacology. 158. (2001). pp:366–373.
. Kalinichev M, Easterling KW, Plotsky PM, Holtzman SG. Long-lasting changes in stress-induced corticosterone response and anxiety-like behaviors as a consequence of neonatal maternal separation in Long–Evans rats. PharmacolBiochemBehav. 73. (2001). pp:131–140.
. Daniels WM, Pietersen CY, Carstens ME, Stein DJ. Maternal separation in rats leads to anxiety-like behavior and a blunted ACTH response and altered neurotransmitter levels in response to a subsequent stressor. Metab Brain Dis. 19. (2004). pp:3–14.
. McIntosh J, Anisman H, Merali Z. Short- and long-periods of neonatal maternal separation differentially affect anxiety and feeding in adult rats: gender-dependent effects. Dev Brain Res. 113. (1999). pp:97–106.
. Pryce CR, Feldon J. Long-term neurobehavioural impact of the postnatal environment in rats: manipulations, effects and mediating mechanisms. NeurosciBiobehav Rev. 27. (2003). pp:57–71.
. Prut, L; Belzung C. "The open field as a paradigm to measure the effects of drugs on anxiety-like behaviors: a review." European Journal of Pharmacology. 463 (1-3). (2003). pp: 3–33.
. Pellow S, File SE. Anxiolytic and anxiogenic drug effects on exploratory activity in an elevated plus maze: a novel test of anxiety in the rat. Pharmacol. Biochem. Behav. .24. (1986).pp: 525.
. Willner P, Towell A, Sampson D, Muscat R, Sophokleous S. Reduction of sucrose preference by chronic mild stress and its restoration by a tricyclic antidepressant. Psychopharmacology .93. (1987). pp:358–364.
. Kalinichev M, Easterling KW, Holtzman SG. Early neonatal experience of Long-Evans rats results in long-lasting changes in morphine tolerance and dependence. Psychopharmacology. 157.(2001). pp: 305–12.
. Caldji C, Francis D, Sharma S, Plotsky PM, Meaney MJ. The effects of early rearing environment on the development of GABAA and central benzodiazepine receptors levels and novelty-induced fearfulness in the rat. Neuropsychopharmacology. 22.(2000). pp: 219–29.
. Meaney MJ, Brake W, Gratton A. Environmental regulation of the development of mesolimbic dopamine systems: a neurobiological mechanism for vulnerability to drug abuse. Psychoneuroendocrinology. 27.(2002). pp: 127–38.
. Workel JO, Oitzl MS, Fluttert M, Lesscher H, Karssen A, de Kloet ER Differential and age-dependent effects of maternal deprivation on the hypothalamic–pituitary–adrenal axis of brown Norway rats from youth to senescence. J Neuroendocrinol.13.(2001).pp:569–580.
. Faraday MM. Rat sex and strain differences in responses to stress. PhysiolBehav.75.(2002). pp:507–522.
. VazquezDM,EskandariiR,ZimmerCA,LevineS,LopezJF. Brain 5-HT receptor system in the stressed infant rat: implications for vulnerability to substance abuse. Psychoneuroendocrinology.27.(2002).pp:245–272.
. Becker C, Thiebot MH, Touitou Y, Hamon M, Cesselin F, Benoliel JJ. Enhanced cortical extracellular levels of cholecystokinin-like material in a model of anticipation of social defeat in the rat. J Neurosci.21. (2001). pp:262–269.
. ShlikJ,VasarE, BradwejnJ.Cholecystokinin and psychiatric disorders. CNS Drugs .8.(1997). pp:134–152.
. Daugé V, Léna I. CCK in anxiety and cognitive processes. NeurosciBiobehav Rev .22.(1998). pp:815–825.
. Carden S, Hofer M. Socially mediated reduction of isolation distress in rat pups is blocked by naltrexone but not by RO15-1788. BehavNeurosci. 104.(1990). pp: 457–64.
. Harris JC, Newman JD. Combined opiate/adrenergic receptor blockade enhances squirrel monkey vocalization. PharmacolBiochemBehav.31. (1988). pp: 223–26.
. Agmo A, Barreau S, Lemaire V. Social motivation in recently weaned rats is modified by opiates. DevNeurosci. 19.(1997). pp: 505–20.
. Uvnas-Moberg K. Gastrointestinal hormones in mother and infant. ActaPaediatr Scand.351. (1989). pp: 88–93.
. Antonijevic IA, Murck H, Bohlhalter S, Frieboes RM, Holsboer F, Steiger A. Neuropeptide Y promotes sleep and inhibits ACTH and cortisol release in young men. Neuropharmacology. 39(8).(2000). pp:1474-81.
. Husum H, Termeer E, Mathe AA, Bolwig TG, Ellenbroek BA. Early maternal deprivation alters hippocampal levels of neuropeptide Y and calcitonin-gene related peptide in adult rats. Neuropharmacology. 42(6).(2002). pp:798-806.
. Roques BP, Beaumont A, Daugé V, Fournié-Zaluski MC. Peptidase-inactivation of enkephalins: design of inhibitors, biochemical, pharmacological and clinical applications. In: Herz A, ed. Handbook of experimental pharmacology. Part I, opioid. New York: Springer- Verlag. 104.(1993).pp: 545–82.
